TyrocoreTM is REVA’s proprietary iodinated desaminotyrosine polycarbonate based polymer designed specifically for vascular scaffolds.

  • Uniquely designed for vascular scaffolds
  • Derived from naturally occurring tyrosine amino acid
  • Covalently bound iodine for radiopacity
  • Proprietary, patent protected, and manufactured by REVA Medical

Tyrocore is Uniquely Designed for Vascular Scaffolds

Tyrocore Offers Improved Properties Compared to PLLA

Properties of Tyrocore versus PLLA

Attribute Tyrocore PLLA1 Benefit
Ultimate Tensile Strength 100-110 MPa 50-70 MPa Thinner struts
Radial strength
Elongation at Break (Ductility) 120-200% 2-10% Single-step inflation
Larger expansion range
X-Ray Visible Yes No Accurate placement

A single Fantom scaffold contains < 1% of the iodine found in 1 mL of contrast media

Tyrocore Radiopacity

Tyrocore Radiopaciy

Tyrocore Biocompatibility for Excellent Vessel Healing

0-3 Months

  • Fantom struts are covered with mature endothelium
    • Substantially fewer adherent platelets than the Absorb control

4-12 Months

  • Fantom shows no adverse reactions as vessel uncages
    • No calcification at the interface between the tissue and the scaffold, which is observed with Absorb

1-~4 Years

  • Fantom final degradation and benign resorption

Tyrocore versus PLLA Degradation and Resorption

0-12 Months – Degradation

  • Absorb has an early peak of lactic acid associated with coating degradation
  • Fantom has minimal lactic acid

1-~4 Years – Resorption

  • Absorb has a large lactic acid peak between 18 and 42 months associated with scaffold resorption
  • Fantom lactic acid concentration is two orders of magnitude lower than Absorb during scaffold resorption

Arterial Wall Lactic Acid Concentration
during Scaffold Degradation

Computational Model

Learn more about Tyrocore

EuroPCR 2018 Presentation
EuroPCR 2018 Presentation

Technical Summary
Technical Summary

Tyrocore Whitepaper
Tyrocore Whitepaper


  1. 1) Poly(Lactic acid): Synthesis, Structure, Properties, and Applications. Edited by R.Auras, L-T.Lim, S.E.M.Selke, H.Tsuji. 2010 John Wiley & Sons, Inc.; p.141